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Home - Products - Membrane Transporter/Ion Channel - Monocarboxylate Transporter - 7-(Diethylamino)coumarin-3-carboxylic acid

7-(Diethylamino)coumarin-3-carboxylic acid

CAS No. 50995-74-9

7-(Diethylamino)coumarin-3-carboxylic acid( DEAC | Coumarin D 1421 | D 1421 )

Catalog No. M20458 CAS No. 50995-74-9

7-(Diethylamino)coumarin-3-carboxylic acid(7ACC) selectively affects a single part of the MCT symporter translocation cycle leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistance and side effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    7-(Diethylamino)coumarin-3-carboxylic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    7-(Diethylamino)coumarin-3-carboxylic acid(7ACC) selectively affects a single part of the MCT symporter translocation cycle leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistance and side effects.
  • Description
    7-(Diethylamino)coumarin-3-carboxylic acid(7ACC) selectively affects a single part of the MCT symporter translocation cycle leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistance and side effects.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    DEAC | Coumarin D 1421 | D 1421
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Monocarboxylate Transporter
  • Recptor
    MCT1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    50995-74-9
  • Formula Weight
    261.27
  • Molecular Formula
    C14H15NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:32 mg/mL (122.48 mM)
  • SMILES
    CCN(CC)c1ccc2cc(C(O)=O)c(=O)oc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Draoui N Schicke O Seront E et al. Antitumor Activity of 7-Aminocarboxycoumarin Derivatives a New Class of Potent Inhibitors of Lactate Influx but Not Efflux[J]. Molecular Cancer Therapeutics 2014 13(6):1410-1418.
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